BACKGROUND: Age-related macular degeneration (AMD) is a common cause of blindness worldwide. Neovascular AMD (nAMD) is an advanced form of the disease, in which excess …Read more
Category: Drug Whisperer
Serum BNP may be Inversely Correlated with Thyroid Hormone Sufficiency in Cardiac Tissues
BACKGROUND: Cardiac re-expression of fetal genes in patients with heart failure (HF) suggests the presence of low cardiac tissue thyroid hormone (TH) function. However, serum …Read more
Could Low-Dose Naltrexone be a Viable Option for Some Psoriasis Patients?
OBJECTIVE: To determine the efficacy of low dose naltrexone in the patients of psoriasis. STUDY DESIGN: Non-randomised clinical trial. PLACE AND DURATION OF STUDY: Department …Read more
Olanzapine may Alleviate Nausea and Vomiting Associated with Advanced Cancer
IMPORTANCE: Nausea and vomiting, unrelated to chemotherapy, can be substantial symptoms in patients with advanced cancer. OBJECTIVE: To evaluate the utility of olanzapine for treating …Read more
Could Post-Exposure Application of Imiquimod Cream at the Inoculation Site Prevent Systemic Infection of Mosquito-Borne Viruses?
ABSTRACT: Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The abundance of genetically distinct arbovirus species, coupled with …Read more
If You Need to Prescribe an Antidepressant for Major Depressive Disorder in the Elderly, SSRIs are Probably the Safer Options
OBJECTIVES: To assess adverse effects of pharmacologic antidepressants for treatment of major depressive disorder (MDD) in adults 65 years of age or older. DESIGN: Systematic review …Read more
Be Careful When Adding Allopurinol in Patients with Heart Failure
ABSTRACT: Several trials have been completed in patients with heart failure (HF) treated with uric acid (UA)-lowering agents with inconsistent results. We aimed to investigate …Read more
Could Rapamcin be Used in the Prevention of Alzheimer’s Disease in the Near Future?
ABSTRACT: Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with aging …Read more
Now We Have a Better Understanding Why Beta-Blockers May Cause Psoriasis Exacerbation in Some People
ABSTRACT: Oxidative stress and Th17 cytokines are important mediators of inflammation. Treatment with beta-adrenoceptor (ADRB) antagonists (beta-blockers) is associated with induction or aggravation of psoriasis-like …Read more
Sitagliptin Looks Promising as Potential Treatment for Women Suffering from Recurrent Pregnancy Loss
BACKGROUND: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of …Read more