BACKGROUND: There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of …
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Low-Dose Short-Term Monotherapy with Glucocorticoids May be an Option to DMARDs in Newly Diagnosed Rheumatoid Arthritis Patients
BACKGROUND: The ACR/EULAR recommendations endorse the use of glucocorticoids (GCs) for rheumatoid arthritis (RA) patients’ flares and as a bridge to a DMARD. However, the recommendation …
Read moreAdding Metformin to Locally-Advanced NSCLC Undergoing Chemotherapy May Reduce the Treatment Benefit and Increase the Side-Effects
IMPORTANCE: Unresected locally advanced non-small cell lung cancer (LA-NSCLC) shows poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether metformin, a diabetes agent that inhibits the …
Read moreCould Low-Dose Colchicine Reduce the Risk of Secondary Heart Attack?
OBJECTIVES: This study investigates risk for major adverse cardiovascular events in relation to history and timing of prior ACS, to determine whether the benefits of …
Read moreLong-Term Use of PPIs is Associated with More Than Two-Fold Increase in The Risk of Developing Gastric Cancer, Regardless of H. Pylori Eradication Status
OBJECTIVE: The association between proton pump inhibitor (PPI) use and gastric cancer related to Helicobacter pylori eradication has not been fully investigated in geographical regions with high risk …
Read moreIn addition to Genital Warts, Topical Sinecatechins may Also Help Vulvar Intraepithelial Neoplasia
OBJECTIVE: To compare the safety and efficacy of 10% sinecatechins (Veregen® ) ointment against placebo in the treatment of usual type vulvar intraepithelial neoplasia (uVIN). DESIGN: A Phase …
Read moreSublingual Immunotherapy and Subcutaneous Immunotherapy are Equally Effective as a Hay Fever Treatment
OBJECTIVES: To determine whether subcutaneous immunotherapy (SCIT) or sublingual immunotherapy (SLIT) better improves patient outcomes and quality of life for adults with allergic rhinitis or rhinoconjunctivitis …
Read moreSome Hypothyroid Patients Might be Deprescribed Levothyroxine Successfully
BACKGROUND: Levothyroxine (LT4) is one of the most commonly prescribed medications. Although considered a life-long replacement therapy, LT4 therapy can be discontinued for some patients. …
Read moreTopical Erythropoietin could Assist in the Healing of Diabetic Foot Ulcer
ABSTRACT: The diabetic foot ulcer (DFU) is a major disabling complication of diabetes mellitus. Growing evidence suggests topical erythropoietin (EPO) can promote wound healing. The …
Read moreFor Patients 75 Years of Age, It may not be A Good Idea to Control Blood Pressure Below 130/80 mmHg
BACKGROUND: Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit …
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