IMPORTANCE: Phase 3 trials have not compared semaglutide and liraglutide, glucagon-like peptide-1 analogues available for weight management. OBJECTIVE: To compare the efficacy and adverse event profiles of …
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Sildenafil for Alzheimer’s Disease Prevention? Maybe Improved Endothelial Function and Circulation Is the Underlying Mechanism
ABSTRACT: We developed an endophenotype disease module-based methodology for Alzheimer’s disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on retrospective …
Read moreShould EECP Be Incorporated into the Treatment of Long-COVID Patients?
SUMMARY: A small study presented at a virtual meeting of the American College of Cardiology found that enhanced external counterpulsation therapy, normally used to treat chest …
Read moreAspirin Should be Prescribed Cautiously in Patients at Risk of Heart Failure or Having Heart Failure
AIMS: Recent trials evaluating the effect of aspirin in the primary prevention of cardiovascular disease showed little or no benefit. However, the role of aspirin …
Read moreLow-Dose IL-2 Might Activate Innate Lymphoid Cells Type 2 and Improve Post-MI Heart Function
BACKGROUND: Innate lymphoid cells type 2 (ILC2s) play critical homeostatic functions in peripheral tissues. ILC2s reside in perivascular niches and limit atherosclerosis development. OBJECTIVES: ILC2s also reside …
Read moreFor Hepatocellular Cancer Patients, Maintaining a Healthy Albumin Level Goes a Long Way to Improving Survival Odds
INTRODUCTION: We evaluated the prognostic significance of the preoperative albumin-to-globulin ratio (AGR) in patients with hepatocellular carcinoma (HCC) with various liver etiologies. METHODS: We retrospectively analyzed 157 …
Read moreIntra-articular Injections Of Platelet-Rich Plasma Better Than Hyaluronic Acid, Corticosteroids, and Plasma Rich In Growth Factors In Treating Osteoarthritis
BACKGROUND: In younger patients and those without severe degenerative changes, the efficacy of intra-articular (IA) injections as a nonoperative modality for treating symptomatic knee osteoarthritis (OA)-related …
Read moreCould Early Addition Of Statin Therapy Improves Overall Survival of Triple-Negative Breast Cancer Patients?
BACKGROUND: Previous studies have examined the association of statin therapy and breast cancer outcomes with mixed results. The objective of this study was to investigate the …
Read moreIt May Be Wise to Recommend Vitamin D3 Supplementation In Cancer Patients Taking Immune Checkpoint Inhibitors
BACKGROUND: There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of …
Read moreLow-Dose Short-Term Monotherapy with Glucocorticoids May be an Option to DMARDs in Newly Diagnosed Rheumatoid Arthritis Patients
BACKGROUND: The ACR/EULAR recommendations endorse the use of glucocorticoids (GCs) for rheumatoid arthritis (RA) patients’ flares and as a bridge to a DMARD. However, the recommendation …
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