Q: I recently purchased Boluoke®, and was wondering if the supplement still OK if it was subjected to high temperatures (approximately 100 degrees) for an extended period of time? Sam Moore (Unknown)
A: Boluoke® (lumbrokinase) is stable for at least 2 years when stored under room temperature (less than 30 degrees Celsius, or 86 degrees Fahrenheit). When the temperature gets above 65 degrees Celsius (149 degrees Fahrenheit), it gets inactivated in about 10 minutes.
Thus, if the bottle has been subject to high heat for an extensive period of time, it’s probably safer for you to get a new bottle, especially if your condition is a serious one. Or you may consult your recommending physician about this.
Q: I have a patient with hyperfibrinogenemia (started with fibrinogen >600, has improved to 440 using nattokinase 100 mg titrated now to 5 caps bid. I believe lumbrokinase to be a better option but am not sure if there are any guidelines regarding making the change. I met with your Boluoke® rep at the recent ISOM conference in April in Vancouver. Please advise. Wendy R., MD (Upland, CA)
A: There is no simple conversion chart between the two enzymes. The usual protocol for lumbrokinase is 2 cap tid for 3-4 weeks, then re-test the fibrinogen level. If the level has reached ideal (less than 350), then the dose would be reduced to 1 cap tid.
If the hyperfibrinogenemia is secondary to some kind of inflammatory or infectious process, then the underlying cause also needs to be addressed. Otherwise, the fibrinogen level may still fluctuate.
Q: I wanted to purchase some of your Boluoke® for my son. When reading the contraindications, “lumbar puncture” is listed. Does this mean if you had a recent lumbar puncture or ever had a lumbar puncture? My son has had a lumbar puncture, but it was a couple of years ago. I just wanted to make sure it was safe for him to take. Thank you. Rachael O. (Unknown)
A: The statement means a recent lumbar puncture procedure or surgery. If it’s been more than 2 weeks and there’s no complication, it is ok to take Boluoke®.
Because Boluoke® (lumbrokinase) is a relatively expensive product with very specific actions, it is advised that you seek medical advice in the proper use of this enzyme preparation in order to obtain the maximal benefit.