A Novel Treatment For Alzheimer’s Dementia — NAD+

DMB Feature Article (May-June 2016)

By Deborah Ardolf, MA, ND

I received a distressed phone call from the daughter of the- soon-to-be-patient. The daugh- ter reportedly had accompanied her father Walter to a neurolo- gist after noticing a dramatic decline in his day-to-day func- tions. Where he previously ran/ walked/hiked the local trails and completed tasks such as daily crossword puzzles, Walter now spent almost all his free time at home watching tv in isolation. His communication style was significantly less expressive and his gait deteriorated from a confi- dent stride to an unsteady shuffle.

Despite Walter’s protests, the daughter took him to see a neurologist.Walter was diagnosed with Alzheimer’s of the dementia type and was deemed unsafe to live by himself. However, Walter wanted to continue living at his own house and stay independent. Believing that her father was still safe to live by himself and also respecting of his wishes, the daughter helped out by bringing meals to the father while taking care of some of the house chores. Later on they learned that the neurolo- gist had unfairly filed a report with adult protective services. The daughter called my office pleading for help; she was deter- mined to find a viable treatment that would help maintain her fa- ther’s independent living status.

Upon conducting the initial consultation with Walter, it became clear that I would be required to rely on my specialties in Speech-language pathology and in Naturopathic medicine.In order to obtain vital information, I carefully altered my questions by making changes to my delivery. By speaking in a simplified and deliberate manner, I was able to communicate with Walter in order to investigate pertinent history. Apparently, the onset of his memory loss occurred a decade ago after surviving a serious rear end collision.While the car was demolished, Walter was found walking aimlessly around the intersection in a confused and dazed state. A second head injury occurred after being hit and knocked unconscious by an assailant armed with a broken empty wine bottle.

At the time of the initial consult, Walter presented with delayed and halting speech and with great difficulty completing his thoughts. His face was free of expression (stone face) and he had involuntary finger movements called cog wheeling. Treatment recommendations included completing a minimum of three days of intravenous NAD+ treatment. If progress was made, then he was to continue the treatment for two more days. Walter agreed.

Walter’s first treatment went fairly well. Upon returning to the clinic to receive day two of treat- ment, Walter had already experienced positive results. With overwhelming surprise and joy, the daughter reported that Walter was able to recount stories about her deceased mother including memories of their married life that she had never heard previously. This fact alone was more than she could wish for.

After the third day of treatment,Walter’s level of comprehension and mental faculties improved significantly. In addition, Walter no longer shuffled his feet nor had an abnormally delayed response time. I recalled Walter sauntering down the hallway to- wards the exit after the third day of treatment. When I raised the volume of my voice to say good- bye, Walter turned his head and partially his body to acknowledge receipt and understanding.Walter was once again able to live inde- pendently on his own. Satisfied with his progress, Walter decided not to return for two more days of treat- ment as was suggested. I did not hear from the family until two years later when they found him unconscious in his own home. It was observed that he had not eaten his din- ner. After receiving intravenous fluids, specifically Lactated Ringer’s, Walter returned to consciousness.The MRI of the brain was negative.

Walter’s change in this condition begs the question: How was his amazing recovery made possible? The answer lies in the implementation of a little known however historically broadly used co-enzyme called NAD+. NAD+ was first discovered by two British biochemists Harden and Young in 1906. However, it was not until the new millennium, that scientists discovered its role in cell to cell communication. NAD+ is released from neurons into our blood vessels to be dispersed throughout the vital organs of our body.

The most vital transmission of NAD+ occurs in the brain. However, in order to get the medicine into the brain at a high enough concentration to be reparative, the medicine must be administered intrave- nously at a very slow rate. Patients should be placed in quiet, calm and low-stress environments conducive to brain healing. 

Note: Appetite is often decreased but quickly returns on completion of the day’s treatment.


Dr. Ardolf graduated from Southwest College of Natural medicine in 2009. She currently practices medicine on the Big Island of Hawaii. She is available for private consultations and will be conducting training semi- nars in the near future. (808) 498-4018 www.drardolf.com