The Triple Therapy of Hydrocortisone-Vitamin C-Thiamine may Reduce the Mortality Rate in Septic Shock Children

AUTHOR CONTRIBUTIONS: All authors made substantial contributions to the conception or design of the study. Drs. Sanchez-Pinto, Wald, Smith, Malakooti and Barhight were responsible for the analysis and interpretation of data for the work. Dr. Wald wrote the first draft and all authors had vital roles in revising it critically as well as viewed the final work product. All authors agree to be accountable for all aspects of the work, including accuracy and integrity.

IMPACT: Our study highlights a potentially valuable metabolic adjuvant therapy for children who are critically ill. This is the first pediatric study to show that the relatively inexpensive combination of parenteral hydrocortisone, ascorbic acid and thiamine may be associated with reduced mortality in children with septic shock.


Wald EL, et al. Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock. Am J Respir Crit Care Med. 2020 Apr 1;201(7):863-867. doi: 10.1164/rccm.201908-1543LE.